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Prion Diseases Section

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Laboratory Details

Mycobacteriology, Vector-borne and Prion Diseases
1015 Arlington Street
Winnipeg, Manitoba
R3E 3R3
Phone #:
(204) 789-6078
(204) 789-5009

The Prion Diseases Section provides national reference services in support of health care professionals dealing with suspected cases of Creutzfeldt-Jakob Disease (CJD).  Accredited CJD testing includes the detection of increased amounts of protein markers of disease found in patients’ cerebrospinal fluid (CSF).  The levels of two indirect markers of disease, gamma 14-3-3 and total tau are measured by enzyme-linked immunosorbent assay (ELISA) based tests. The presence of the pathogenic prion protein in CSF is detected  by end-point quaking-induced conversion (EP- QuIC) assay.   These CSF based tests are offered as a panel.  Collectively the test results support diagnoses of CJD.

The Prion Diseases Section supports further investigation of CJD cases by providing genetic sequence analysis of PRNP (the gene encoding the prion protein). Sequence analyses confirm or exclude the presence of mutations linked to inherited prion diseases.  Due to the privacy considerations surrounding sequencing of patient DNA, consent must be obtained prior to this analysis being performed.  Consent forms are available through the CJD Surveillance System: 1-888-489-2999. 

Proficiency Panels

Proficiency Panel Reports

Requisition Form

Reference Diagnostic Tests

Reference Diagnostic Tests
PathogenTest CategoryReference Diagnostic Test
Creutzfeldt-Jakob Disease (CJD) Sequencing PRNP Gene Sequencing
Creutzfeldt-Jakob Disease (CJD)/Prions Host Marker Cerebrospinal Fluid (CSF) Test Panel